One thing, if youll humor me here, Im trying to get better about doing is reading the guest bio before the actual conversation begins. Your body decreases energy levels in response to being under attack. Okay. You remind me when you made the earlier comment, which was also fascinating by the way that the adrenal supports oftentimes support mitochondrial function. It is. So purely by having excess body fat on your body, your mitochondria are always responding like theres danger present in the body. There are several easy steps to follow. The research Ive seen on fasting thus far is not that compelling. He hosts the Energy Blueprint podcast and he has also been studying and involved in health for more than 25 years. Gut-butt too right? Mitochondrial dysfunction happens when the function of mitochondria is reduced. As youre saying that Im seeing this split screen in my mind, on the one hand, your analogy coming to life. I have histamine intolerance, which formula is best? L-Carnitine has been discussed as a supplement that can help keep your heart and mitochondria healthy. Because the standard American diet has given rise to a widespread sugar addiction, most people tend to burn glucose. So I have no opposition to that at all. So Dr. Ruscio, DC recommends talking to your doctor about your caloric goals, and then if you do decide to add it in, just start slow. Hey there. MitoQ is a world-first, mitochondria-targeted CoQ10 antioxidant. Healthy Gut, Healthy You, my book and your complete self-help guide to healing your gut. But if someones not sleeping well, has a poor circadian rhythm, is not exercising, and isnt maybe doing sauna or contrast therapy, what have you, these are really important foundational aspects to have in place first and should be weighted with equal or more emphasis than some sort of, even an evidence-based, mitochondrial supplement. And it actually rarely comes up in interviews so Im relishing this opportunity. And so we want to intervene upstream so as to allow the body to shut off this defense response and therefore allow the mitochondria to produce the appropriate level of energy that they should. And I ended up spending about a year of my life digging into the literature on, specifically, on adrenal function and HPA axis function as it relates to chronic fatigue, ultimately coming to the conclusion that the research really didnt support the idea that the adrenals were the cause of fatigue. "The chief reason for mitochondrial burnout is the consumption of processed, empty-calorie foods." Yeah, me too. So when Mary Sue (and theres not a Mary Sue who I dont like and I always pick on guys, but thats just the example we always use in terms of the name you just throw on that avatar), when she goes and reads about the thyroid problem causing her thinning hair, her fatigue, her depression, and her constipation and then she goes and sees a provider and he says, yes, its your thyroid take this pill, itll make you feel better. And what do you know, when she says, gosh, you know what? Some experience big longevity benefits. But these are not common causes of chronic fatigue. And you sent me a sample of, I believe it was mitogenesis is the name of the formula that you made, and Im wondering. I want you to start focusing on your circadian rhythm and sleep habits and get those dialed in. Yeah. And Ive been studying nutrition and health science more broadly since I was a little kid. So what that means is the loss of mitochondria is actually a product of lack of hormetic stress, lack of challenging your mitochondria through hormetic stressors, like various types of exercise, breath-holding practices, heat exposure, cold exposure, phytochemicals, [etc]. Theres also research on how it modulates levels of inflammation, which is another mechanism of how it works. Increase the level of omega-3 fats in your diet to help build your mitochondrial membranes. I have no problem with fasting and I can. Dr. Joel Kahn provides the answer. Ill also mention, just to add to that a bit, that there are some people who might be listening to this thinking, well, I got my cortisol tested and I really do have low cortisol levels. Okay. In mitochondrial disease, the mitochondria don't work well or don't work at all. And you may see a falsely low mitochondrial function test because what youre seeing is a quantification of the end result not necessarily at the cause. Yeah. Right. Why is Mitochondrial Health Important? - spermidineLIFE by Longevity It means they are switching out of energy mode into defense mode. What if I have a whey or milk protein allergy? He hosts the Energy Blueprint podcast and he has also been studying and involved in health for more than 25 years. Without mitochondria, we would end up with significantly less ATP. Mitochondria supply your cells with vital energy. Exactly. They dropped poison gas in the streets. The One Easy Thing You Can Do Daily To Keep Your Mitochondria Healthy This is called apoptosis (programmed cellular death). Increasing your protein intake throughout the day can help keep your mitochondria in optimal health. That is not because from today where youre feeling good and healthy and tomorrow where youve got the symptom of fatigue, because you have a flu. Although, spoiler alert, you probably dont want to perform this test. Hear about the probiotic protocol to follow. We should be careful about trying to quantify mitochondrial dysfunction or get too swept up in assessing and or supporting mitochondrial function because, again, a lot of this dysfunctionthe symptoms that well see mainly of fatigue are a byproduct of the fact that the body is shutting down energy production as a protective response. Thats fantastic. 5 Ways to Boost Your Mitochondrial Capacity - Bicycling Like what you do when youre under attack is you seal things off, you close yourself in, and you stop your normal routines. And write a compelling article, right? And in fact, for example, Rhodiola and all those different adaptogenic herbs that I just mentioned are well established to act directly on the mitochondria to stimulate mitochondrial biogenesis, mitochondrial growth, to upregulate the NRF2 pathway and the ARE (the antioxidant response element) to build up a more robust internal antioxidant system at the mitochondrial level. I have to say Im actually shocked at the level at which foundational nutrition and lifestyle habits are ignored in favor of exotic solutions. If you are taking this supplement, how do you know that you're taking it safely? We start to pull on these levers and we can create positive, upward spirals of physiological input that improve the health and the function of every system of our body. With a lot of tasks to perform, it's important to keep your mitochondria healthy. Its an important tool of in the arsenal. The brain and liver are also very energy dependent and have lots of mitochondria. . The Role of Mitochondria: How to Keep It Healthy Im talking in, if you tested those people who, again, dont even have the symptom of fatigue, theyre healthy people, but theyre simply night owls. Well, the good news is its actually not just a normal product of the aging process itself. Take your vitamins. Compared to moderate continuous intensity training and high-intensity interval training (HIIT . And all of a sudden the Russians started attacking. Ari introduced a concept that is far different than most of what youll hear, I believe anyway, in functional health chatter regarding mitochondria. But is this one maybe fair to say is the most accurate? But before we get there, so as to make sure we dont go to the 201 level discussion, maybe just frame for people from a high level a reminder what the mitochondria are, why theyre important, and then some of the basics in terms of mitochondrial health. 10 Ways to Boost Your Mitochondria - Metabolic Meals - Blog And hes discussed with us in the past many techniques for optimizing mitochondrial function and this should be a nice continuation of that. Well, you can order our whey-free version of our Elemental Heal. There isn't a cure, but treatment can prevent life-threatening complications. The following discussion is for educational purposes only and is not intended to diagnose or treat any disease. And its 2022 with the best of modern medicine and all this sophisticated technology and all this fancy research, of course, theyre going to be able to do a blood test on me and figure out whats causing my fatigue. And 95% of the time they tell they can tell you nothing about whats causing your fatigue. Alpha Lipoic Acid, CoQ10, fish or krill oil, magnesium, B vitamins, L carnitine, PQQ, and glutathione are recommended by Designs for Health Australia. Thats DRRUSCIO.com. But just to impress the point that if you fish for enough cherry picked mechanisms and spin those into an attractive description, you can motivate people to buy or to act. Mitochondrial Health: 5 Ways to Improve Cellular Energy - DrJockers.com Work with Dr. Ruscios, DC, Health Coach! He discusses that mitochondrial dysfunction is often a reaction, a protective reaction known as a cellular defense response, and he did an excellent job helping us to better appreciate that. And there are many other examples like this of tests that are commonly used that are just not well validated. How protein can support your mitochondrial health You can support your mitochondria by eating plenty of protein. Its so challenging, I think, to be a health consumer. So my personal journey was that I dealt personally, when I was in my mid twenties, with severe chronic fatigue after a bout of heavy mononucleosis. Because depending on what I want to convince people of, I can go cherry pick a study or two that supports almost any narrative. But if you give someone ginseng or Rhodiola theres evidence showing that these things help. But the problem with it is that it only identifies something in five out of every 100 cases for people with chronic fatigue. This article contains scientific references. And the reason why, the mechanism, is actually those phospho lipids get digested intact and actually make it to our cells where they end up helping to replace and repair damaged mitochondrial membrane so mitochondria can work better and produce more energy. Keeping your heart and mitochondria healthy is important. L-Carnitine So let me give you a specific breakdown. (2) The Ruscio Institute is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. Let me give you some specific numbers and data on this. Thats DRRUSCIO.com. So some of the research thats been done linking fasting with longevity is actually cherry picked in that regard. I think thats, thats so important. And we could have put together a whole spurious argument about your mitochondria need to convert these electrons and this is the backbone of ATP. So just visit drruscio.com/EH. Would this be the formula that you would say for someone in this position, now Im asking selfishly as a clinician, would that be where you would start someone or is there a different supplement? And they are that, they are energy generators and they are incredibly important in that role. Exactly. Now lets head to the show. The very brief summary of a year of my life is this: that research overwhelmingly shows no discernible connection, no correlation whatsoever between cortisol levels, adrenal function, and the symptom of fatigue. Its called NT factor. Now actually just to make the point, loop it back in with testing, I would actually argue that if that type of testing was easy to do, if it didnt involve sticking a big hollow needle in your thigh and taking a chunk of muscle tissue out, which is pretty painful and most people dont want to do that, that test would actually be extraordinarily insightful because how many mitochondria you have in your cells, your total mitochondrial capacity is enormously important to determining your cellular energy producing capacity. Overall, I would say that my impressions are this: I am open to the possibility that longer term fasting probably does has have some unique benefits in terms of maybe activating stem cells or rejuvenating immune function or gut health or something like that. We try to do the exact opposite of that. And so this, I think is a key question to ask and it may have been, Im not sure what they correlated against, but I guess what you found when looking at it was a subjective wellness measure that it was attempted to be correlated to show poor agreement between the test and, lets say, subjective wellbeing or energy indices, Im assuming. Theres our store where you can find our Elemental Diet line, our probiotic line, and other health and gut-supportive supplements. And Im sure you will benefit from this just really rich unpacking of this topic of mitochondrial health. I actually love what you just said and Im so happy you brought it up because I love talking about this particular topic because I find that not a lot of people understand it very well. And in general, the research that comparesI mean, this is not a perfect illustration of the point you were just makingbut there are studies that compare daily calorie restriction to intermittent fasting approaches and in general, they show no significant differences between the two groups. And that is to (this is going to sound really primitive), but it is to physically count the number of mitochondria in your cells. And 33 of the 59 studies found no discernible difference whatsoever in cortisol levels. Our team of licensed nutritionists and dietitians strive to be objective, unbiased, honest and to present both sides of the argument. Yeah, no, thats the supplement for sure. How To Keep Your Mitochondria Healthy For Better Energy Why we shouldnt cherry pick. Conversely, within the conventional medical realm, I already mentioned that they do testing that is clinically well validated. I havent. 25 years of research all over the world that has tested the relationship of HPA axis function and cortisol levels to these various fatigue syndromes, and overwhelmingly that body of evidence shows no correlation between the symptom of fatigue and cortisol levels. There are a number of other studies that have found certain markers associated with mitochondrial function, carnitine, Coq10, things like that are lower in people with chronic fatigue. Mitochondrial Health - Performance Medicine So youre suppressing levels of this critically important mitochondrial protective compound that gets into our mitochondria and actually recharges the internal ARE (antioxidant response element). Like I said, over 80% of people. With a lot of tasks to perform, it's . Theres also research looking at how it modulates neurological function and neurotransmitter levels in the brain. Wonderful. And then I prescribe to them [] Rhodiolaginsengashwaganda. And Ari made a fantastic point that I was not aware of fully, that many adrenal supports actually also help to support and bolster not only mitochondrial function, but neurotransmitters function as anti-inflammatories. 100%. Yeah, same here my friend. And so, alright. Yeah. And he had to start taking boatloads of supplements, which he didnt necessarily want to and didnt feel any differently. Cutting the Power: Understanding Mitochondrial Disease - Healthline Tune in to the podcast to hear our discussion. Several amino acids (glycine, cysteine, and glutamic acid) make up glutathione. Every product is science-based, validated by real-world use, and personally vetted by Dr. Ruscio, DC. What Is Mitochondrial Dysfunction? | Tru Niagen So Ari is the founder of the Energy Blueprint System, a comprehensive lifestyle and supplement program, which has helped more than 2 million people around the world to have better health, performance, and energy. 7 Ways to Support Your Mitochondria - YouTube Again, were not recommending these tests because the validity is questionable, but just looking at that one example of you may have a false positive in that case. And so if someone says, I felt better from adrenal support, we should be very careful not to conclude erroneously that it was because there was some sort of adrenal dysfunction. But its also the case that functional health is riddled with tests that are not well validated and that are largely speculative. Well, all right. But he has a new book out today, Eat For Energy. And then from there now they have the energy to start to implement some of those foundational nutrition and lifestyle habits. And this is really the distillation of my over 25 years of study of that topic, specifically. Whats been missing in conversations about fatigue 14:39 Yeah. And the test dont delineate this, right? It recharges our internal antioxidant defense system with glutathione and catalyses and superoxide dismutase so that mitochondrial protection system and detoxification system can work properly the following day. And let me add a few nuances to what you just said specific to this topic of mitochondria. Mitochondria are often referred to as the powerhouses of the cell. But they also say, this is more directly related to what youre saying about thyroid and adrenals, they also talk about testing in people with chronic fatigue and they say, this is actually in the paper, they say that only in 5% of cases does anything show up on the lab tests that is an explanatory factor in their fatigue. Meaning 95% of the time, 95 out of every 100 people that come in with chronic fatigue have nothing detectable on their lab test that shows up that can explain their chronic fatigue. Why? I dont feel like I have my hands around this fully yet, in terms of the formula. Well go with that too. Eat fewer calories. Its like youre lifting weights and targeting your muscles or youre going for a run. And its been shown in studies. All-In-One Triple Therapy Probiotic Powder Sticks, Elemental Heal (Gut-healing Meal Replacements), Want Healthier Relationships? This is Erin Ryan from the Dr. Ruscio, DC team answering a few of the top questions about our elemental heal. And finally, there is our clinicians newsletter, the FFHR, AKA the Future of Functional Health Review database with research reviews, case studies, and other helpful resources for healthcare providers. New updates to gut research cover what interventions help with IBS, leaky gut, and an overactive immune system. ARTICLE SUMMARY Mitochondria generate 90 percent of the body's energy, powering the cells to perform vital functions. How to start addressing the causes of mitochondrial defense syndrome 01:02:56 So the point is we have to be cautious with how we interpret certain events and if our a priori assumptions are inaccurate, then our conclusions will also be inaccurate. Is it safe to produce energy? And youre not, but many, many of them are because there is this attitude that Ive seen so many people take of almost assuming that everybody is already dialed in, in terms of their nutrition and lifestyle habits. And just wondering if you have any thoughts? Theyre deciding whether the bodys going to be in energy mode or defense mode and where on that spectrum the bodys going to operate. And sometimes I feel so, so bad for healthcare consumers who are trying to educate themselves because you can be very convincing, but you can be making a convincing argument out of really poor data. You can learn a lot more about our elemental heal formulas at drruscio.com/EH. So Ari is the founder of the Energy Blueprint System, a comprehensive lifestyle and supplement program, which has helped more than 2 million people around the world to have better health, performance, and energy. That is incredibly insightful to know, and I hope this is resonating with our listeners as much as it is for myself in that we want to stop looking at adrenals and thyroid as this ubiquitous cause of problems with energy. All of those recommendations are very, very likely to make dramatic improvements in that persons health.
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